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What is Melanotan 2 Peptide?

Melanotan 2 peptide, often referred to as MT-2, is a synthetic analog of the naturally occurring melanocortin peptide hormone alpha-melanocyte-stimulating hormone (α-MSH). It is primarily known as a skin tanning peptide, for its ability to stimulate melanin production in the skin, leading to darkening pigmentation and an increased tan and bronzed skin when exposed to UV radiation. 

Melanotan 2 works by binding to melanocortin receptors in the skin, triggering the production of melanin and providing a protective mechanism against sun damage. This peptide has been shown in clinical studies to achieve a tan without prolonged sun exposure, potentially reducing the risk of sunburn and skin damage.

Molecular Formula: C50H69N15O9

Sequence: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)-NH2

Molecular Weight: 1024.2 g/mol

View the HPLC Certificate here

Source: PubChem

Melanotan 2 Structure

Benefits of Melanotan 2 Peptide

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The Mechanism of Action of Melanotan 2

Research has demonstrated that Melanotan 2 peptide exerts its effects primarily by interacting with melanocortin receptors in the body, specifically the MC1R receptor, which is found on melanocytes in the skin. When Melanotan ii binds to these receptors, it activates a series of biochemical pathways that result in increased production of melanin, the pigment responsible for skin colour.

By stimulating melanin production, Melanotan 2 promotes skin darkening, leading to a tan-like appearance. This process mimics the natural tanning response that occurs when the skin is exposed to UV radiation but without the need for extensive sun exposure.

Additionally, the increased melanin levels induced by Melanotan ii can provide some level of protection against UV radiation, potentially reducing the risk of sunburn and other sun-related skin damage.

Furthermore, studies indicate that Melanotan 2 may have potential applications beyond tanning, as research suggests it could play a role in appetite suppression and sexual arousal due to its interactions with melanocortin receptors in the brain. However, more studies are needed to fully understand the extent of Melanotan 2’s effects on these physiological processes.

Studies have established the side effects of Melanotan ii peptide may include nausea, vomiting, facial flushing, and appetite suppression. It currently remains an unregulated product.

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Melanotan 2 Applications


Studies have suggested that the melanocyte stimulating hormone, Melanotan 2, can achieve a darker skin pigmentation without the risks of excessive sun exposure.

Melanotan ii was first discovered by researchers looking for methods of treating skin cancer. They hypothesised that an animal’s natural pigmentary system could be stimulated to produce a safe and protective tan before UV exposure. Thus reducing the risk of skin damage in animals during studies.

A small amount of UV exposure stimulates melanin production from the skin’s melanocytes. Melanotan 2 has been shown to be effective on all skin types in animals.

Melanotan II has demonstrated its ability to promote melanogenesis with minimal side effects. Melanogenesis can protect the hypodermis, which is the layer beneath the skin, from harmful UV-B rays. In addition, absorbing all UV-B light prevents penetration into the skin [1].

Fat loss

Mexico Clinical studies have shown significant results when using Melanotan 2 for weight loss. During studies using animal models, Melanotan II appears to lower fat storage and decrease appetite. Food preferences and intake are influenced by the MC-4R (melanocortin-4 receptor). Not only has MT-2 shown to reduce food intake in mice models but scientific research has suggested it alters their desire for fatty foods.

Mice administered with Melanotan II are found to reject fatty foods they would otherwise enjoy. Similarly, mice lacking the melanocortin-4 receptor eat primarily fat and are unaffected by MT-2. Leptin, which can lessen cravings and food intake, has similar effects to MT-2. However, leptin has never been found to be effective in treating obesity, or even in individuals that have insufficient leptin [2].

Mexico Scientific research found that melanotan ii has the ability to reduce appetite by making the user consume less, in addition to reducing visceral and subcutaneous fat. Furthermore, it  has been shown to increase metabolism and activity, all of which cause weight loss [3].

Sexual dysfunction

Men commonly treat erectile dysfunction (ED) with Viagra and other medications that primarily improve blood flow by lowering vascular resistance. However, not all erectile dysfunction is caused by vascular issues, and therefore Viagra (sildenafil) and similar medications are ineffective in a small percentage of men and the vast majority of women.

MT-2 appears to have a much broader application due to its effects on the central nervous system. Eighty per cent of men during clinical investigations who had a failed response to Viagra responded well to MT-2 therapy. Melanotan II has been extensively researched as a potential treatment for both male and female sexual desire disorders. Thus, Melanotan 2 is a well-studied peptide in terms of human behaviour, sexual desire, and impulse control [4].

Impulse control and alcohol

Mexico Scientists researching this peptide have found that it may influence oxytocin signalling and thus behaviour in alcohol dependant individuals.  In addition, melanotan 2 seems to work synergistically with naltrexone (boosting efficacy by over sevenfold) to reduce binge-like ethanol intake in subjects [5].

Furthermore, as well as being an effective alcoholism treatment, these findings suggest that MT-2 taps into a fundamental process of cravings and desire in mammals. Also, the role that oxytocin plays in impulsive behaviour may be clarified by further research. It could help scientific researchers identify the craving pathways and lead to a better understanding in human motivation in areas such as work and relationships [6].

Buy Melanotan 2 Pre-Mixed Peptide Pen. Pen kits and pre-mixed refill cartridges supplied by PharmaLabGlobal Mexico for research purposes.

Is Melanotan different from Melatonin?

While both names sound similar, Melanotan and Melatonin serve very different purposes in the body, with Melanotan primarily affecting skin pigmentation and Melatonin primarily influencing sleep regulation. It’s important to be aware of this distinction when considering the use of these substances for their intended purposes.

Melanotan 2 FAQs

What’s the difference between Melanotan 1 and Melanotan 2?

Melanotan 1 and Melanotan 2 are both synthetic peptides designed to stimulate melanin production in the skin, leading to increased pigmentation. While both peptides serve this primary purpose, they differ in their mechanisms of action and potency. Melanotan 1 is known for providing a slower, more gradual tan compared to Melanotan 2, which typically produces a faster and darker tan. Additionally, Melanotan 2 has been found to have appetite suppressant effects and may cause more frequent side effects like nausea and flushing, whereas Melanotan 1 is generally considered milder in terms of side effects.

What are the differences between Melanotan 2 and PT-141?

Whilst PT-141 is a variant of Melanotan, Melanotan 2 is primarily researched for tanning it may have indirect effects on libido due to its melanogenesis-stimulating properties, whereas PT-141 directly targets sexual function by activating melanocortin receptors in the brain. Therefore, Melanotan 2 is more commonly associated with tanning benefits alongside potential secondary effects on libido and appetite, whereas PT-141 is specifically focused on addressing sexual dysfunction and enhancing sexual experiences.

Is Melanotan 2 legal?

As of the most recent information available, the legal status of Melanotan 2 varies by country and jurisdiction. In some regions, Melanotan 2 is considered a controlled substance or unauthorized in the general population for human use due to safety concerns and regulatory restrictions. It’s important for individuals considering the use of Melanotan 2 to research and comply with the laws and regulations governing its purchase and usage in their specific location.

Scientific Research

[1] Abdel-Malek Z, Swope VB, Suzuki I, Akcali C, Harriger MD, Boyce ST, Urabe K, Hearing VJ. Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1789-93. 

[2] van der Klaauw A, Keogh J, Henning E, Stephenson C, Trowse VM, Fletcher P, Farooqi S. Role of melanocortin signalling in the preference for dietary macronutrients in human beings. Lancet. 2015 Feb 26;385 Suppl 1(Suppl 1):S12.

[3] Côté I, Sakarya Y, Kirichenko N, Morgan D, Carter CS, Tümer N, Scarpace PJ. Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction. Can J Physiol Pharmacol. 2017 Feb;95(2):206-214.

[4] Wessells H, Fuciarelli K, Hansen J, Hadley ME, Hruby VJ, Dorr R, Levine N. Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study. J Urol. 1998 Aug;160(2):389-93.

[5] Navarro M, Carvajal F, Lerma-Cabrera JM, Cubero I, Picker MJ, Thiele TE. Evidence that Melanocortin Receptor Agonist Melanotan-II Synergistically Augments the Ability of Naltrexone to Blunt Binge-Like Ethanol Intake in Male C57BL/6J Mice. Alcohol Clin Exp Res. 2015 Aug;39(8):1425-33. 

[6] York DA, Boghossian S, Park-York M. Melanocortin activity in the amygdala influences alcohol intake. Pharmacol Biochem Behav. 2011 Mar;98(1):112-9.


Further Reading:

Top Peptides for Improved Immunity

Discover the peptides which are currently under investigation for immune system support, including Melanotan 2, Thymalin, Thymosin Alpha-1 and Ipamorelin. 

Find out which peptides can boost your immune system here.

PT-141 and Kisspeptin Revolutionizing Sexual Disorder Treatment

Explore the advantages that PT-141 another peptide, which like Melanotan ii, is a synthetic melanocortin can exhibit when used in conjunction with Kisspeptin, including increased sexual desire.

Discover the benefits that PT-141 and Kisspeptin combination can offer.

Tanning with Peptides: The Future of a Healthy Tan with Peptides

Find out about how lotions can give a healthy tan without the need of UV rays. Also discover the science which is evolving to develop tanning peptides, including any associated serious side effects.  

Check out the full blog here.

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